Uday Singh awarded AHA Postdoctoral Fellowship
Uday Singh, a postdoctoral fellow in Dr. Huxing’s laboratory, has been awarded a Postdoctoral Fellowship (#19POST34450083) from the American Heart Association (AHA) for his project entitled “The role of PVN MC4R circuits in obesity-associated hypertension”. This grant proposal will study how neurons in the paraventricular nucleus of hypothalamus (PVN) regulate sympathetic nerve activity (SNA) affecting cardiovascular function. Sympathetic overactivity is a key feature in obesity-induced hypertension, a significant risk factor for the development of cardiovascular diseases including stroke, myocardial infarction and congestive heart failure. While it is known that the PVN plays an important role in the regulation of SNA, the underlying neural circuits through which PVN neurons mediate obesity-associated sympathetic overdrive and hypertension is not fully understood. This proposal will provide critical information on how PVN neurons contribute to obesity-associated hypertension.